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Significance and strategies in developing delivery systems for bio-macromolecular drugs

Huining HE, Qiuling LIANG, Meong Cheol SHIN, Kyuri LEE, Junbo GONG, Junxiao YE, Quan LIU, Jingkang WANG, Victor YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4,   Pages 496-507 doi: 10.1007/s11705-013-1362-1

Abstract: the unmatched reaction efficiency and a repetitive action mode, the therapeutic activity of a single bio-macromolecularHence, bio-macromolecular drugs have been recognized around the world as the future “drug-of-choice”.Yet, among the>10000 drugs that are currently available, only ~150 of them belong to these bio-macromolecularIn general, the bottleneck limitations of these bio-macromolecular drugs are two-fold: (1) the absenceSince worldwide progress on bio-macromolecular therapeutics still remains in the infant stage and thus

Keywords： delivery systems     bio-macromolecular drugs     cell penetrating peptides    

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Developing macromolecular therapeutics: the future drug-of-choice

Huining HE, Victor C. YANG, Weibing DONG, Junbo GONG, Jingkang WANG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 10-17 doi: 10.1007/s11705-009-0291-5

Abstract: Macromolecular drugs including peptides, proteins, antibodies, polysaccharides and nucleic acids haveDue to their unmatched properties of high selectivity and efficiency, macromolecular drugs have beenwide open for equal-ground competition, R&D related to macromolecular drugs should be considereddrugs are reviewed.drugs with self-owned intellectual property rights, are provided.

Keywords： worldwide     challenging     effective     macromolecular     self-owned intellectual    

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Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 404-415 doi: 10.1007/s11684-021-0834-9

Abstract: Although various strategies have been used to study anti-ZIKV agents, approved drugs or vaccines forRepurposing clinically approved drugs could be an effective approach to quickly respond to an emergencyThe well-established safety profiles and optimal dosage of these clinically approved drugs could providefocuses on the recent research and development of agents against ZIKV infection by repurposing clinical drugs

Keywords： Zika virus     clinical drugs     ZIKV inhibitors     antivirals     repurposing    

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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Frontiers of Medicine doi: 10.1007/s11684-023-1037-3

Abstract: So far, a few small-molecule antiviral drugs, including nirmatrelvir–ritonavir (Paxlovid), remdesivirTo date, four domestically developed oral anti-COVID-19 drugs have been granted conditional market approvalThese drugs include azvudine, simnotrelvir–ritonavir (Xiannuoxin), leritrelvir, and mindeudesivir (VV116understanding and highlight the potential widespread application of China’s homegrown anti-COVID-19 drugs

Keywords： COVID-19     antiviral drugs     mindeudesivir    

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Synthesis and characterization of macromolecular surface modifier PP--PEG for polypropylene

CHEN Hanjia, SHI Xuhua, ZHU Yafei, ZHANG Yi, XU Jiarui

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 1,   Pages 102-108 doi: 10.1007/s11705-008-0018-z

Abstract: A novel macromolecular surface modifier, polypropylene-grafted-poly(ethylene glycol) copolymer (PP--PEGthat PP--PEG could diffuse preferably onto the surface of the blends and be suitable as an effectual macromolecular

Keywords： polypropylene     crystallization capacity     attenuated     hydrophilicity     reflectance    

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Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1140-5

Abstract:

We developed a method for determining 11 abused drugs in water and

METH and EPH were the dominant drugs in water

Abuse drugs in Beiyunhe River were mainly from

Abused drugs in the water would not impair the

Keywords： Drugs of abuse     Occurrence     Distribution     Urban river     Environmental risk    

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Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 815-826 doi: 10.1007/s11684-021-0891-0

Abstract: Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL)Hematology, Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugsfor Chinese BCL patients on the basis of the current application status of oral drugs in China, combinedThis consensus reviewed the application of oral drugs in the treatment of BCL and the latest researchand provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients

Keywords： B-cell lymphoma     oral drug     targeted therapy     immunotherapy     COVID-19 pandemic    

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Surgical robotics: A look-back of latest advancement and bio-inspired ways to tackle existing challenges

Yang LIU, Jing LIU

Frontiers of Mechanical Engineering 2012, Volume 7, Issue 4,   Pages 376-384 doi: 10.1007/s11465-012-0352-1

Abstract: perform an exhaustive evaluation, we would emphasize more on the new insight by digesting the emerging bio-inspiredAs an alternative, bio-inspired methods or materials may shed light on new innovations.

Keywords： minimally invasive surgery     surgical robotics     haptic feedback     miniaturization     bio-inspiration     bionics    

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Bio-based Technologies for Resource Recovery

Aijie Wang, David Stuckey

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 4, doi: 10.1007/s11783-018-1079-y

Abstract:

Keywords： valign=     top     class=     J_zhaiyao    

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Combustion characteristics and kinetics of bio-oil

Ruixia ZHANG, Zhaoping ZHONG, Yaji HUANG

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 2,   Pages 119-124 doi: 10.1007/s11705-009-0068-x

Abstract: The combustion characteristics of bio-oils derived from rice husk and corn were studied by thermogravimetryin air and nitrogen atmosphere, we analyzed the combustion characteristics of different kinds of bio-oilsin different atmospheres and worked out the combustion kinetics parameters of the bio-oil, providingreliable base data for the burning of bio-oil.The thermogravimetry indicated that the combustion process of bio-oil was divided into three stages.

Keywords： bio-oil     combustion characteristics     combustion kinetics    

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Prospect and Technology Progress of Bio-diesel Industry

Ji Xing,Xi Xiaolin,Kong Linhe,Li Junfeng,Li Li

Strategic Study of CAE 2002, Volume 4, Issue 9,   Pages 86-93

Abstract:

The current situation of research, application and development of bio-diesel industry all over theworld is reviewed in this article, and the problem in the preparation and application of bio-dieselThe importance of bio-diesel industry to the national petroleum supply, national economy and re-adjustmentThe prospect and development pattern of bio-diesel industry in China are pointed out as well.

Keywords： bio-diesel     bio-diesel preparation     bio-diesel industry    

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nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 387-404 doi: 10.1007/s11705-014-1457-3

Abstract: challenges in developing efficient and target specific delivery systems of small molecule and nucleic acid drugs

Keywords： nanocarrier     cellular uptake     endosomal release     nucleic acid drug    

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Production of renewable fuels by blending bio-oil with alcohols and upgrading under supercritical conditions

Sainab Omar, Suzanne Alsamaq, Yang Yang, Jiawei Wang

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 4,   Pages 702-717 doi: 10.1007/s11705-019-1861-9

Abstract: The work studied a non-catalytic upgrading of fast pyrolysis bio-oil by blending under supercriticalCharacterisation of the bio-oil and the upgraded bio-oils was carried out including moisture content,The GCMS analysis indicated that the supercritical methanol reaction removed the acids in the bio-oilconsequently the pH increased from 2.39 in the crude bio-oil to 4.04 after the supercritical methanolthe O content and increasing the heating value to 27.55 from 17.51 MJ·kg in the crude bio-oil.

Keywords： bio-oil     blending     supercritical     upgrading     characterisation    

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volatile organic sulfur compounds in off-gas mixture from a wastewater treatment plant using a two-stage bio-trickling

Shihao Sun, Tipei Jia, Kaiqi Chen, Yongzhen Peng, Liang Zhang

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 4, doi: 10.1007/s11783-019-1148-x

Abstract:

A two-stage BTF system was established treating odorous off-gas mixture from a WWTP.

The two-stage BTF system showed resistance for the lifting load of H2S and VOSC.

Miseq Illumina sequencing showed separated functional microbial community in BTFs.

Avoiding H2S inhibition and enhancement of VOSC degradation was achieved.

Key control point was discussed to help industrial application of the system.

Keywords： Odor     Two-stage bio-trickling filter process     Bio-trickling filter     Hydrogen sulfide     Volatile organic sulfur    

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A review on catalytic & non-catalytic bio-oil upgrading in supercritical fluids

Sainab Omar, Yang Yang, Jiawei Wang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 1,   Pages 4-17 doi: 10.1007/s11705-020-1933-x

Abstract: This review article summarizes the key published research on the topic of bio-oil upgrading using catalyticThe precious metal catalysts Pd, Ru and Pt on various supports are frequently chosen for catalytic bio-oilesterification, which leads to improvements in liquid yield, heating value, and pH of the upgraded bio-oilOn the other hand, SCFs have been effectively used to upgrade crude bio-oil without a catalyst.

Keywords： bio-oil     upgrading     supercritical     review    

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Title Author Date Type Operation

Significance and strategies in developing delivery systems for bio-macromolecular drugs

Huining HE, Qiuling LIANG, Meong Cheol SHIN, Kyuri LEE, Junbo GONG, Junxiao YE, Quan LIU, Jingkang WANG, Victor YANG

Journal Article

Developing macromolecular therapeutics: the future drug-of-choice

Huining HE, Victor C. YANG, Weibing DONG, Junbo GONG, Jingkang WANG,

Journal Article

Repurposing clinical drugs is a promising strategy to discover drugs against Zika virus infection

Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang

Journal Article

Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

Journal Article

Synthesis and characterization of macromolecular surface modifier PP--PEG for polypropylene

CHEN Hanjia, SHI Xuhua, ZHU Yafei, ZHANG Yi, XU Jiarui

Journal Article

Occurrence, distribution and risk assessment of abused drugs and their metabolites in a typical urban

Peng Hu, Changsheng Guo, Yan Zhang, Jiapei Lv, Yuan Zhang, Jian Xu

Journal Article

Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition)

Journal Article

Surgical robotics: A look-back of latest advancement and bio-inspired ways to tackle existing challenges

Yang LIU, Jing LIU

Journal Article

Bio-based Technologies for Resource Recovery

Aijie Wang, David Stuckey

Journal Article

Combustion characteristics and kinetics of bio-oil

Ruixia ZHANG, Zhaoping ZHONG, Yaji HUANG

Journal Article

Prospect and Technology Progress of Bio-diesel Industry

Ji Xing,Xi Xiaolin,Kong Linhe,Li Junfeng,Li Li

Journal Article

nanocarriers for efficient cellular uptake and endosomal release of small molecule and nucleic acid drugs

Vaibhav Mundra, Ram I. Mahato

Journal Article

Production of renewable fuels by blending bio-oil with alcohols and upgrading under supercritical conditions

Sainab Omar, Suzanne Alsamaq, Yang Yang, Jiawei Wang

Journal Article

volatile organic sulfur compounds in off-gas mixture from a wastewater treatment plant using a two-stage bio-trickling

Shihao Sun, Tipei Jia, Kaiqi Chen, Yongzhen Peng, Liang Zhang

Journal Article

A review on catalytic & non-catalytic bio-oil upgrading in supercritical fluids

Sainab Omar, Yang Yang, Jiawei Wang

Journal Article